Multiple murine BRaf^V600E melanoma cell lines with sensitivity to PLX4032

Abstract excerpt

Rates of melanoma are steadily on the rise, with a current lifetime incidence of 1 in 50 individuals (Balch et al., 2004; Smalley et al., 2005). In nearly 50% of human melanomas, the BRAF oncogene encodes BRAFV600E (Lee et al., 2011; Long et al., 2011; Menzies et al., 2012; Rubinstein et al., 2010), a protein whose expression increases melanoma progression via activation of signaling cascades and downstream genes...

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