Article

Melanomagenesis driven by a kinase-dead mutant BRAF lacking codons 600-618

2021-08-20

Abstract excerpt

<h4>ABSTRACT</h4> While considerable success has been achieved with treating BRAF-V600E mutant tumors in several organ systems, tumors expressing non-V600E BRAF mutations remain a significant clinical challenge. Such atypical BRAF mutations are classified based on their kinase activity, RAS-dependence and their requirement for dimerization to function. We identified an unusually large in-frame deletion in a melan...

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Literature Corpus work: 104782fc-59f4-5b67-99c4-da6524482b34
DOI: 10.1101/2021.08.20.457149

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