Effects of rapamycin on social interaction deficits and gene expression in mice exposed to valproic acid in utero

Abstract excerpt

The mammalian target of rapamycin (mTOR) signaling pathway plays a crucial role in cell metabolism, growth, and proliferation. The overactivation of mTOR has been implicated in the pathogenesis of syndromic autism spectrum disorder (ASD), such as tuberous sclerosis complex (TSC). Treatment with the mTOR inhibitor rapamycin improved social interaction deficits in mouse models of TSC. Prenatal exposure to valproic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autism Spectrum Disorder Research
• Share to Genetics and Neurodevelopmental Disorders
• Share to Neurogenetic and Muscular Disorders Research