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Genotype-Epigenome-Phenotype Integration Reveals the Contributions of Peripheral Immune Cells to Bipolar Disorder Pathogenesis, Phenotypic Heterogeneity, and Therapy

2025-03-18

Abstract excerpt

Immune dysfunctions are believed to contribute to bipolar disorder (BD), yet their mechanistic basis remains unclear. To address this, we systematically characterize BD-associated epigenomic and genetic variation in peripheral blood immune cells by profiling and integrating 833 genome-wide maps of five histone modification marks across 180 individuals (88 Type I BD patients, 92 controls), coupled with whole-genome...

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Literature Corpus work
97e412ca-ceb9-5faa-a666-730cd35d243f
DOI
10.1101/2025.03.17.25324124
Open publication

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Genotype-Epigenome-Phenotype Integration Reveals the Contributions of Peripheral Immune Cells to Bipolar Disorder Pathogenesis, Phenotypic Heterogeneity, and TherapyDOI 10.1101/2025.03.17.25324124
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