Article
Trans-ancestry genome-wide analyses of bipolar disorder in East Asian and European populations improve genetic discovery.
Nature neuroscience - 1 Feb 2026
Zhang Chu-Yi, Li Miao, Sun Ping, Hui Li, Gao Yuan, Yang Jian-Zhong, Zhang Nan, Feng Xiaoyang, Wu Yong, Guo Lei, Yuan Jing, Jiang Hong-Yan, Cheng Yu-Qi, Ma Simeng, Gong Qian, Sun Yaoyao, Li Yi, Qu Na, Yin Xu-Yuan, Wang Lu, Yang Yongfeng, Wang Chuansheng, Lv Luxian, Zhou Dongsheng, Li Xingxing, Chen Xiaogang, Zhang Chen, Chen Jun, Song Xueqin, Tang Jinsong, Cai Jun, Fan Weixing, Tang Wei, Tang Wenxin, Li Wenqiang, Tang Xia, Zhang Xiaoxi, Lu Yan, Yao Yong-Gang, Wang Chuang, So Hon-Cheong, Iwata Nakao, Ikeda Masashi, Saito Takeo, Liu Zhongchun, Xu Shuahua, Yue Weihua, Fang Yiru, Zhu Feng, Xiao Xiao, Li Ming
Abstract excerpt
Genome-wide association studies (GWASs) of bipolar disorder (BD) have predominantly included individuals of European (EUR) ancestry, underrepresenting non-EUR populations and limiting insight into disease mechanisms. Here we performed a GWAS of BD in Han Chinese individuals (5,164 cases and 13,460 controls) and conducted comparative and integrative analyses with independent East Asian (EAS, 4,479 cases and 75,725...
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