Article
DNA methylation signatures associated with bipolar disorder in peripheral blood improve prediction models.
EBioMedicine - 1 Jun 2026
Tesfaye Markos, Stavrum Anne-Kristin, Höffler Kira D, O'Connell Kevin S, David Friederike S, Garrett Melanie E, Hesam-Shariati Sonia, Overs Bronwyn J, Pisanu Claudia, Spano Luana, Watkeys Oliver J, Weihs Antoine, Ardau Rafaella, Ashley-Koch Allison E, Athanasiu Lavinia, Beckham Jean C, Bourassa Kyle J, Chillotti Caterina, Djurovic Srdjan, Drange Ole K, Frank Josef, Khayachi Anouar, Kimbrel Nathan A, Martorell Lourdes, Meinert Susanne, Melle Ingrid, Morken Gunnar, Paribello Pasquale, Pinna Marco, Roberts Gloria, Rouleau Guy, Schofield Peter R, Sepúlveda Esteban, Severino Giovanni, Steen Vidar M, Stein Frederike, Streit Fabian, Lagerberg Trine Vik, Alda Martin, Dannlowski Udo, Forstner Andreas J, Fullerton Janice M, Grabe Hans J, Green Melissa J, Kircher Tilo, Labad Javier, Manchia Mirko, Mitchell Philip B, Soares Jair C, Squassina Alessio, Teumer Alexander, Tondo Leonardo, Vilella Elisabet, Andreassen Ole A, Chaumette Boris, Fries Gabriel R, Le Hellard Stephanie
Abstract excerpt
BACKGROUND: Bipolar disorder (BD) is a major mood disorder influenced by both genetic and environmental factors. While DNA methylation from peripheral tissues can reflect both genetic and environmental influences and reveal insights into disease biology, it remains understudied in BD. DNA methylation signatures may complement polygenic scores (PGS) and hold potential as biomarkers. Here, we conducted the largest...
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