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Genetics of bipolar disorder: Translating discoveries to biological insights and clinical decision support.

Psychiatry and clinical neurosciences - 1 Jul 2026

Hindley Guy, Koch Elise M, Parker Nadine, Shadrin Alexey A, Smeland Olav Bjerkehagen, Frei Oleksandr, O'Connell Kevin S, Andreassen Ole A

Abstract excerpt

Bipolar disorder (BD) is a clinically heterogenous mental disorder with a diversity in clinical trajectories and treatment response. Twin studies have shown that BD is highly heritable, with estimates ranging from 60% to 90%. However, our understanding of this genetic component has yet to be translated into clinical interventions or prediction tools. In this review, we summarize findings from large-scale...

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PMID: 42093104
DOI: 10.1111/pcn.70067

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