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Article

Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.

Nature communications - 15 May 2026

Hou Lei, Li Yue, Xiong Xushen, Tanigawa Yosuke, Park Yongjin, Lenz Samuel W, Grayson Amy, Lee Jeong-Heon, Ryu Euijung, Olson Janet E, Biernacka Joanna M, Frye Mark A, Ordog Tamas, Kellis Manolis

Abstract excerpt

Immune dysfunction has been increasingly implicated in bipolar disorder, but the underlying mechanisms remain unclear. To address this, we profile 833 genome-wide chromatin immunoprecipitation sequencing datasets spanning five histone marks in peripheral blood immune cells from 88 Type I bipolar disorder patients and 92 controls, integrating them with whole-genome sequencing and clinical data. We identify...

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Identifiers

PMID: 42140902
DOI: 10.1038/s41467-026-72543-0
PMCID: PMC13434788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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