Article

A small increase in <i>CHEK1</i> activity leads to the arrest of the first zygotic division in human

2020-12-26

Abstract excerpt

The first mitotic division in mammalian zygotes is unique. The fertilized egg reactivates its cell cycle, and the maternal and paternal genomes start to reprogram to become totipotent. The first division is very sensitive to a range of perturbations, particularly the DNA damage, leading to the embryo's failure to enter the first mitosis. We discovered that a point mutation in the human CHEK1 gene resulted in an A...

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Literature Corpus work: 97dc08e3-274a-5c31-bfbd-389635b987d3
DOI: 10.1101/2020.12.26.424381

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