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mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in <i>Trypanosoma brucei</i>

2023-02-23

Abstract excerpt

Trypanosoma brucei and related kinetoplastid parasites possess unique RNA processing pathways, including in their mitochondria, that regulate metabolism and development. Altering RNA composition or conformation through nucleotide modifications is one such pathway, and modifications including pseudouridine regulate RNA fate and function in many organisms. We surveyed pseudouridine synthase (PUS) orthologs in Trypan...

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Literature Corpus work
97cc52c7-9862-5adb-b946-a09e144e0fbf
DOI
10.1101/2023.02.23.529727
Open publication

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