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A pseudouridylation switch in rRNA is implicated in ribosome function during the life cycle of Trypanosoma brucei

4 May 2016

Abstract excerpt

The protozoan parasite Trypanosoma brucei, which causes devastating diseases in humans and animals in sub-Saharan Africa, undergoes a complex life cycle between the mammalian host and the blood-feeding tsetse fly vector. However, little is known about how the parasite performs most molecular functions in such different environments. Here, we provide evidence for the intriguing possibility that pseudouridylation...

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PMID: 27142987
DOI: 10.1038/srep25296

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