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Mitochondrial unfolded protein response (UPR mt ) as novel therapeutic targets for neurological disorders

15 May 2025

Abstract excerpt

Neurological disorders, including brain cancer, neurodegenerative diseases and ischemic/reperfusion injury, pose a significant threat to global human health. Due to the high metabolic demands of nerve cells, mitochondrial dysfunction is a critical feature of these disorders. The mitochondrial unfolded protein response (UPR mt ) is an evolutionarily conserved mitochondrial response, which is critical for...

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PMID: 40370320
DOI: 10.1177/0271678x251341293

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