Article

Arthritis Flares Mediated by Tissue Resident Memory T Cells in the Joint

2021-06-05

Abstract excerpt

Although rheumatoid arthritis is a systemic disease, flares typically occur in a subset of joints that is distinctive for each patient. Pursuing this intriguing pattern, we show that arthritis recurrence is mediated by long-lived synovial resident memory T cells (T RM ). In three murine models, CD8+ cells bearing T RM markers remain in previously inflamed joints during remission. These cells are bona fide T RM...

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Literature Corpus work: 979bced2-d40d-5755-8da0-fe604529f7e6
DOI: 10.1101/2021.06.04.446927

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