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Emerging roles for Mitochondrial Rho GTPases in tumor biology

14 Aug 2024

Abstract excerpt

Mitochondrial Rho GTPases (MIRO1 and MIRO2) are primarily studied for their role as resident mitochondrial anchor proteins that facilitate mitochondria trafficking in neurons. However, it is now appreciated that these proteins have critical roles in cancer. In this review, we focus on examining the role of MIROs in cancer, including expression changes in tumors and the molecular mechanisms by which MIROs impact...

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PMID: 39128718
DOI: 10.1016/j.jbc.2024.107670

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