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Neuropathology of α‐synuclein in Parkinson's disease

31 Mar 2022

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder characterized by progressive movement disability accompanied by non-motor symptoms. The neuropathology hallmark of PD is the loss of dopaminergic neurons predominantly in the substantia nigra pars compacta and the presence of intracellular inclusions termed Lewy bodies (LBs), which are mainly composed of α-synuclein (αSyn). Detailed staging based on the...

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PMID: 35362115
DOI: 10.1111/neup.12812

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