Article

Low-branching vessel architecture shapes immune cell niches and predicts immune responses in renal cancer

2025-06-06

Abstract excerpt

Clear cell renal cell carcinoma (ccRCC) is characterized by marked histological heterogeneity, encompassing its vasculature. Here, we introduce PropSegNet, a learning-based algorithm that segments and classifies three distinct vascular patterns in CD31-stained tissue sections. Integrating transcriptomic features, our work identifies a trajectory from high- to low-branching vessel architecture that co-evolves with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a316b13c-e9d6-5855-bf8c-9cbf542d3eb6
DOI: 10.1101/2025.06.05.25329017

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Low-branching vessel architecture shapes immune cell niches and predicts immune responses in renal cancerDOI 10.1101/2025.06.05.25329017Read

Deep visual multi-omics profiling reveals mechanisms that underlie cancer cell differentiation and aggressiveness in clear cell renal cell carcinomaSemantic proximity Read

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals a tumor-associated endothelial tip cell phenotype.Semantic proximity Read

Single-cell analyses of renal cell cancers reveal insights into tumor microenvironment, cell of origin, and therapy responseSemantic proximity Read

A spatial multi-omic portrait of survival outcome for clear cell renal cell carcinomaSemantic proximity Read

Histopathology based AI model predicts anti-angiogenic therapy response in renal cancer clinical trial.Semantic proximity Read

Prognostic Immunophenotyping Clusters of Clear Cell Renal Cell Carcinoma Defined by the Unique Tumor Immune MicroenvironmentSemantic proximity Read

Single-cell transcriptional profiling of clear cell renal cell carcinoma reveals an invasive tumor vasculature phenotypeSemantic proximity Read

Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapySemantic proximity Read

Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loopSemantic proximity Read

Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancersSemantic proximity Read

Tumor Microenvironment Dynamics in Clear-Cell Renal Cell CarcinomaSemantic proximity Read

Integrative Analysis of Histological Textures and Lymphocyte Infiltration in Renal Cell Carcinoma using Deep LearningSemantic proximity Read