Back to search

Article

Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapy

2021-12-24

Abstract excerpt

<h4>ABSTRACT</h4> Tumor microenvironment (TME) shapes the tumor progression and therapy outcome. Particularly, tumor angiogenesis and immunity impact the effect of immune checkpoint blockade (ICB) therapy. Here, we analyzed the transcriptome from 11,069 patients from The Cancer Genome Atlas (TCGA) to assess 91 functional gene sets corresponding to endothelial and T-cell activity. Intriguingly, TME across 30 non-h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
67db3170-f1bd-538a-8d4a-c83b3fd1ddb2
DOI
10.1101/2021.12.23.470799
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Conserved angio-immune subtypes of the cancer microenvironment predict response to immune checkpoint blockade therapyDOI 10.1101/2021.12.23.470799
Pan-cancer integrative analyses dissect the remodeling of endothelial cells in human cancersSemantic proximity
Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single centerSemantic proximity
Understanding tumour endothelial cell heterogeneity and function from single-cell omics.Semantic proximity
ANGPT1 as a Key Regulator in Tumor Microenvironment and Immunotherapy Response Across Multiple Cancers: A Pan-cancer AnalysisSemantic proximity
Histopathology based AI model predicts anti-angiogenic therapy response in renal cancer clinical trial.Semantic proximity
Dynamic Tumor Immune Microenvironment Remodeling Predicts Response of Checkpoint Inhibitor TherapySemantic proximity
Integrative Identification of Angiogenesis-Related Genes for Predicting Immune Interaction and Prognosis in LUADSemantic proximity
Immune cell clustering identifies a CD163⁺/CSF1R⁺ macrophage and neutrophil-enriched phenotype with distinct biological signatures and poor prognosis in angiosarcoma.Semantic proximity
Pan-Cancer Analysis Reveals Prognostic Potential of ANGPTL2 and Its Implications in Tumor MicroenvironmentSemantic proximity
Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loopSemantic proximity
Comprehensive analysis prediction prognosis and immune therapy value of angiogenesis-associated genes in kidney renal clear cell carcinomaSemantic proximity
Deciphering the Origin and Plasticity of Circulating Endothelial Cells: A Model for Systemic Angiogenesis Programs in Health and DiseaseSemantic proximity
Select a neighboring publication to make it the new centre.