Article

Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T-cell receptors for cancer immunotherapy targeting hotspot driver mutations

2023-11-09

Abstract excerpt

<title>Abstract</title> Hotspot driver mutations presented by human leukocyte antigens (HLAs) can be recognized by antitumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as <italic>PIK3CA</italic><italic>H1047L</italic> may serve as emerging targets for cancer immunotherapies. NetMHC V4.1 were utilized for predicting neo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 975393c6-83f3-510c-aa21-0ef8cd14126f
DOI: 10.21203/rs.3.rs-3544061/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T-cell receptors for cancer immunotherapy targeting hotspot driver mutationsDOI 10.21203/rs.3.rs-3544061/v1Read

Identification of an HLA-A*11:01-restricted neoepitope of mutant PIK3CA and its specific T cell receptors for cancer immunotherapy targeting hotspot driver mutations.Semantic proximity Read

Immunogenicity of a public neoantigen derived from mutated PIK3CASemantic proximity Read

PIK3CA hotspot mutation generates a shared neoantigen targetable by TCR gene therapy.Semantic proximity Read

Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA.Semantic proximity Read

Therapeutic potential of T cell receptor targeting the HLA-A*11:01-restricted KRASG12V neoantigen without cross-recognition of the self-antigen RAB7B in solid tumorsSemantic proximity Read

Adoptive cell therapy targeting common p53 neoantigens in human solid cancersSemantic proximity Read

Identification and Validation of T-cell Receptors Targeting RAS Hotspot Mutations in Human Cancers for Use in Cell-based Immunotherapy.Semantic proximity Read

Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discoverySemantic proximity Read

Dual-degenerate TCRs target multiple KRAS hotspot and HLA-A3 family combinationsSemantic proximity Read

Genomic analysis of 63,220 tumors reveals insights into tumor uniqueness and targeted cancer immunotherapy strategies.Semantic proximity Read

Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognitionSemantic proximity Read

HLA class I restricted epitopes prediction of common tumor antigens in Caucasoid and Oriental ethnic populations: implication on antigen selection for tumor specific CD8+ T cellular immunotherapy and cancer vaccine designSemantic proximity Read