Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys

27 May 2020

Abstract excerpt

Effective delivery of protein therapeutics to the central nervous system (CNS) has been greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB transport vehicle (TV) comprising an engineered Fc fragment that exploits receptor-mediated transcytosis for CNS delivery of biotherapeutics by binding a highly expressed brain endothelial cell target. TVs were engineered using directed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular transport and secretion
Share to Monoclonal and Polyclonal Antibodies Research
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32461332
DOI: 10.1126/scitranslmed.aay1359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeysPMID 32461332Read ↗

NewroBus for the brain: humanized TfR1-targeting nanobodies with high BBB permeability and cargo transport capacitySemantic proximity Read ↗

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene deliverySemantic proximity Read ↗

Novel VHH targeting a unique TfR1 epitope for efficient cross-species delivery of drugs in the CNSSemantic proximity Read ↗

Engineering anti-amyloid antibodies with transferrin receptor targeting improves brain biodistribution and mitigates ARIASemantic proximity Read ↗

The effects of dose, valency, and affinity on TfR-mediated brain delivery in vivoSemantic proximity Read ↗

NN-800s: Brain-penetrant trimeric nanobodies enable potent TNFα inhibition via TfR1-mediated transcytosisSemantic proximity Read ↗

Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrierSemantic proximity Read ↗

Investigating receptor-mediated antibody transcytosis using Blood-Brain Barrier organoid arraysSemantic proximity Read ↗

Selection of phage‐displayed llama single‐domain antibodies that transmigrate across human blood‐brain barrier endotheliumSemantic proximity Read ↗

In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsSemantic proximity Read ↗

Non-Human Primate Blood–Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New ModelSemantic proximity Read ↗

Intracellular Delivery of Peptides and Proteins with an Engineered Membrane Translocation DomainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.