Article

Epigenetic characterization of pseudogenes across human tissues

2025-10-06

Abstract excerpt

Pseudogenes have long been considered non-functional remnants of genome evolution. However, compared to other noncoding elements, their epigenetic regulation remains poorly understood, largely due to their sequence similarity to parent genes and the lack of systematic functional analyses. Here, we leverage matched transcriptomic and epigenomic data from the ENCODE EN-TEx project, spanning ∼30 human tissues, to com...

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Literature Corpus work: 8fc099e9-34fd-5691-8a67-2618d09df434
DOI: 10.1101/2025.10.05.680540

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