Article

The Extracellular Matrix as a Primary Driver of Atypical Neural Topology: Mechanobiology, Volume Transmission, and Allostatic Load in Neurodivergent Architectures

2026-04-01

Abstract excerpt

<p>Background: Genome-wide association studies consistently link neurodevelopmental phenotypes to extracellular matrix (ECM) variants. However, translational psychiatry remains constrained by a "connectome-only" paradigm, failing to resolve systemic pleiotropy, such as the robust overlap with connective tissue hypermobility. The Hypothesis: We propose the High-Processing Cost Phenotype (HPCp) model, driven by a "L...

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Literature Corpus work: 968f5d2a-d551-54da-a3a4-8f7804d6126a
DOI: 10.31234/osf.io/5d6sg_v1

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