Article
Topological signatures differentiating episodic and chronic phenotypes in migraine without aura: a multi-scale analysis revealing divergent network profiles.
The journal of headache and pain - 13 Apr 2026
Lin Chenyu, Dai Chenyu, Hu Yixuan, Zhang Xiaojie, Tao Zi, Liu Xiaoqing, Li Xinhao, Xu Tong, Ye Mengqian, Cao Yungang, Chen Keyang, Liu Kun, Liu Xiaozheng, Fu Fangwang, Li Yan
Abstract excerpt
BACKGROUND: The differences between episodic and chronic migraine phenotypes imply a system-level network reorganization often obscured by traditional discrete analyses. We employed multidimensional functional gradient analysis to characterize these distinct topological patterns and anchor them to microscale mechanisms. METHOD: This study utilized resting-state fMRI in 111 participants with migraine without aura...
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