Article
Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease.
Nature communications - 1 May 2025
Karlinski Zur Maayan, Bhattacharya Bidisha, Solomonov Inna, Ben Dror Sivan, Savidor Alon, Levin Yishai, Prior Amir, Sapir Tamar, Harris Talia, Olender Tsviya, Schmidt Rita, Schwarz J M, Sagi Irit, Buxboim Amnon, Reiner Orly
Abstract excerpt
The viscoelastic properties of tissues influence their morphology and cellular behavior, yet little is known about changes in these properties during brain malformations. Lissencephaly, a severe cortical malformation caused by LIS1 mutations, results in a smooth cortex. Here, we show that human-derived brain organoids with LIS1 mutation exhibit increased stiffness compared to controls at multiple developmental...
Read the complete abstract on PubMedTopics
- Humans
- Extracellular Matrix
- Organoids
- Brain
- Matrix Metalloproteinase 9