Article

Binary partitioning of human brain organization due to divergent human cytoskeletal evolution

2026-05-18

Abstract excerpt

<h4>Summary</h4> CHRFAM7A is a biallelic uniquely human fusion gene present in 99.3% of humans. The direct and inverted alleles likely emerged independently in Africa and East Asia. We uncovered that the inverted allele regulates ULK4 expression through genetic epistasis. The increase in long to short ULK4 isoform ratio enhances α-tubulin acetylation leading to microtubule (MT) cytoskeleton phenotypes (cell bod...

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Literature Corpus work: 8363c9fd-b574-5293-8429-2adc8f0d7684
DOI: 10.64898/2026.05.18.725959

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