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Correlation between BAP1 Localization, Driver Mutations, and Patient Survival in Uveal Melanoma

25 Aug 2022

Abstract excerpt

Uveal melanoma (UM) is an uncommon but highly aggressive ocular malignancy. Poor overall survival is associated with deleterious BAP1 alterations, which frequently occur with monosomy 3 (LOH3) and a characteristic gene expression profile. Tumor DNA from a cohort of 100 UM patients from Moorfields Biobank (UK) that had undergone enucleation were sequenced for known UM driver genes (BAP1, SF3B1, EIF1AX, GNAQ, and...

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PMID: 36077643
DOI: 10.3390/cancers14174105

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