Article
Genetic landscape of uveal melanoma.
Journal francais d'ophtalmologie - 1 Jun 2015
Rodrigues M J, Stern M-H
Abstract excerpt
Uveal melanoma is genetically one of the simplest malignant tumors in adults. Initiation of these tumors is dependent of an oncogenic mutation in the GNAQ or GNA11 genes present in almost all cases. The nature of second mutational events is of major interest as it monosomy 3, gain of 8q and BAP1 inactivation are associated with unfavorable prognosis while SF3BI or EIF1AX are of good prognosis. Despite their...
Topics
- Adult
- Cell Transformation, Neoplastic
- Chromosome Deletion
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 8
- DNA Mutational Analysis
- Eukaryotic Initiation Factor-1
- GTP-Binding Protein alpha Subunits
- GTP-Binding Protein alpha Subunits, Gq-G11
- Gene Expression Regulation, Neoplastic