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Article

Genetic landscape of uveal melanoma.

Journal francais d'ophtalmologie - 1 Jun 2015

Rodrigues M J, Stern M-H

Abstract excerpt

Uveal melanoma is genetically one of the simplest malignant tumors in adults. Initiation of these tumors is dependent of an oncogenic mutation in the GNAQ or GNA11 genes present in almost all cases. The nature of second mutational events is of major interest as it monosomy 3, gain of 8q and BAP1 inactivation are associated with unfavorable prognosis while SF3BI or EIF1AX are of good prognosis. Despite their...

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Share to RNA Splicing Factors
Share to Ribonucleoprotein, U2 Small Nuclear
Share to Chromosomes, Human, Pair 8

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to GTP-Binding Protein alpha Subunits

Share to GTP-Binding Protein alpha Subunits, Gq-G11

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Source

Identifiers

PMID: 25976133
DOI: 10.1016/j.jfo.2015.04.004

Genes

BAP1
GNA11
GNAQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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