Article

The antipsychotic drug pimozide is a novel chemotherapeutic agent for adult T cell leukemia

2021-03-11

Abstract excerpt

<title>Abstract</title> <p>Patients with adult T cell leukemia (ATL), caused by the human T cell leukemia virus type 1 (HTLV-1), exhibit poor prognosis owing to drug resistance. Pimozide, a dopamine D2 receptor subfamily antagonist and antipsychotic drug, has been shown to exhibit anticancer activity. Herein, we investigated whether pimozide exerts anti-ATL effects and explored the mechanisms underlying these eff...

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Literature Corpus work: 96863b35-0edf-5da1-91c9-ce14c08d3db0
DOI: 10.21203/rs.3.rs-272455/v1

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