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Article

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia.

Blood - 19 May 2016

Bellon Marcia, Lu Ling, Nicot Christophe

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1)-associated adult T-cell leukemia and T-cell lymphoma (ATL) are aggressive diseases with poor prognoses, limited therapeutic options, and no curative treatment. In this study, we used a mouse model of ATL and restored expression of the microRNA, miR-124a, to identify in vivo downstream effectors responsible for its tumor-suppressive functions in ATL cells. Our results...

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Source

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Identifiers

PMID: 26813676
DOI: 10.1182/blood-2015-11-685032
PMCID: PMC4874225

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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