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Article

c-MYC and reactive oxygen species play roles in tetrandrine-induced leukemia differentiation

23 Apr 2018

Abstract excerpt

Tetrandrine is a broadly used bisbenzylisoquinoline alkaloid component of traditional Chinese medicine that has antitumor effects in some cancer types. In this study, we investigated the effects of tetrandrine on leukemia in vitro and in vivo. The results showed that tetrandrine effectively induced differentiation and autophagy in leukemia cells. In addition, tetrandrine treatment activated the accumulation of...

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PMID: 29700286
DOI: 10.1038/s41419-018-0498-9

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