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Article

Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway.

eLife - 11 Sept 2024

Besser Elazar, Gelfand Anat, Procaccia Shiri, Berman Paula, Meiri David

Abstract excerpt

In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic transformation. We have previously identified a specific chemovar of Cannabis that induces apoptosis by preventing Notch1 maturation in leukemia cells. Here, we isolated three cannabinoids from this chemovar that synergistically mimic the effects of the whole extract. Two were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 39258755
DOI: 10.7554/eLife.90854
PMCID: PMC11390110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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