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Article

Conserved genes act as modifiers of invertebrate SMN loss of function defects.

PLoS genetics - 28 Oct 2010

Dimitriadi Maria, Sleigh James N, Walker Amy, Chang Howard C, Sen Anindya, Kalloo Geetika, Harris Jevede, Barsby Tom, Walsh Melissa B, Satterlee John S, Li Chris, Van Vactor David, Artavanis-Tsakonas Spyros, Hart Anne C

Abstract excerpt

Spinal Muscular Atrophy (SMA) is caused by diminished function of the Survival of Motor Neuron (SMN) protein, but the molecular pathways critical for SMA pathology remain elusive. We have used genetic approaches in invertebrate models to identify conserved SMN loss of function modifier genes. Drosophila melanogaster and Caenorhabditis elegans each have a single gene encoding a protein orthologous to human SMN;...

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Identifiers

PMID: 21124729
DOI: 10.1371/journal.pgen.1001172
PMCID: PMC2965752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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