Article

The Na <sup>+</sup> /K <sup>+</sup> ATPase Regulates Glycolysis and Modifies Immune Metabolism in Tumors

2020-04-01

Abstract excerpt

Cancer therapies targeting metabolism have been limited due to a lack of understanding of the controlling properties of vulnerable pathways. The Na + /K + ATPase is responsible for a large portion of cellular energy demands but how these demands influence metabolism and create metabolic liabilities are not known. Using metabolomic approaches, we first show that digoxin, a cardiac glycoside widely used in humans,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 967728bb-8030-53f3-9b03-cb86fd80a79a
DOI: 10.1101/2020.03.31.018739

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Na <sup>+</sup> /K <sup>+</sup> ATPase Regulates Glycolysis and Modifies Immune Metabolism in TumorsDOI 10.1101/2020.03.31.018739Read

Cancer therapy–induced cardiac metabolic reprogramming: A new frontier in cardio-oncologySemantic proximity Read

Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.Semantic proximity Read

Bioenergetic properties of human sarcoma cells help define sensitivity to metabolic inhibitorsSemantic proximity Read

Developing the Theory of Toxic Chemotherapeutic Nutrition for Cancer Cells and Targeting Tumors via Glucose Mutation: Medical Guidance and Integrated Therapeutic ApproachSemantic proximity Read

Oncometabolite d-2-hydroxyglutarate impairs α-ketoglutarate dehydrogenase and contractile function in rodent heart.Semantic proximity Read

Developing the theory of Toxic Chemotherapeutic Nutrition for Cancer Cells: Glucosodiene Polymer Structure, Safety, Efficacy, and Human Outcomes in Targeting Tumors via Glucose Mutation.Semantic proximity Read

Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.Semantic proximity Read

Oxaliplatin-induced cardiotoxicity in mice is connected to the changes in energy metabolism in the heart tissueSemantic proximity Read

Sodium chloride in the tumor microenvironment enhances T-cell metabolic fitness and cytotoxicitySemantic proximity Read

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and functionSemantic proximity Read

Reductive carboxylation via isocitrate dehydrogenase 1 supports cardiac metabolic adaptation during oncometabolic stressSemantic proximity Read

Intracellular K <sup>+</sup> limits T cell exhaustion and preserves antitumor functionSemantic proximity Read