Article
Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma.
Nature communications - 22 Aug 2016
Eskiocak Ugur, Ramesh Vijayashree, Gill Jennifer G, Zhao Zhiyu, Yuan Stacy W, Wang Meng, Vandergriff Travis, Shackleton Mark, Quintana Elsa, Johnson Timothy M, DeBerardinis Ralph J, Morrison Sean J
Abstract excerpt
New therapies are required for melanoma. Here, we report that multiple cardiac glycosides, including digitoxin and digoxin, are significantly more toxic to human melanoma cells than normal human cells. This reflects on-target inhibition of the ATP1A1 Na(+)/K(+) pump, which is highly expressed by melanoma. MEK inhibitor and/or BRAF inhibitor additively or synergistically combined with digitoxin to induce cell...
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