Article

Circulating levels of epirubicin cause endothelial senescence while compromising metabolic activity and vascular function

2020-06-26

Abstract excerpt

Anthracycline-based chemotherapy is a common treatment for cancer patients. Because it is delivered intravenously, endothelial cells are exposed first and to the highest concentrations, prior to diffusion to target cells. Not surprisingly, vascular dysfunction is a consequence of anthracycline therapy. While chemotherapy-induced endothelial damage at administration sites has been investigated, the effects of lower...

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Literature Corpus work: 1e990393-f7e8-54c3-9fb4-a5fec0e6e905
DOI: 10.1101/2020.06.25.171249

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