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Article

Targeting the TNFα/TNFR1 axis alleviates the experimental acute pancreatitis

2025-11-25

Abstract excerpt

<title>Abstract</title> <p> <bold>Objective</bold> : Acute pancreatitis (AP) is an inflammatory disorder of the pancreas that can lead to life-threatening systemic inflammation and multiple organ failure with high mortality. The binding of tumor necrosis factor α (TNFα) to its receptor TNFR1 is a key driver of inflammation. Here, we demonstrate that genetic ablation or pharmacological inhibition of TNFR1 allevi...

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Identifiers and source

Literature Corpus work
bc972cbf-0849-59d4-b6ca-ff12e0669249
DOI
10.21203/rs.3.rs-8003658/v1
Open publication

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