Article

CDK12 is Necessary to Promote Epidermal Differentiation through Transcription Elongation

2021-06-01

Abstract excerpt

<h4>ABSTRACT</h4> Proper differentiation of the epidermis is essential to prevent water loss and to protect the body from the outside environment. Perturbations in this process can lead to a variety of skin diseases that impacts 1 in 5 people. While transcription factors that control epidermal differentiation have been well characterized, other aspects of transcription control such as elongation are poorly unders...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 965aee78-7d9c-563a-9441-75bae1039e03
DOI: 10.1101/2021.06.01.446524

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CDK12 is Necessary to Promote Epidermal Differentiation through Transcription ElongationDOI 10.1101/2021.06.01.446524Read

Epigenetic Mechanisms of Epidermal DifferentiationSemantic proximity Read

CDK12: an emerging therapeutic target for cancer.Semantic proximity Read

Gene expression regulation by CDK12: a versatile kinase in cancer with functions beyond CTD phosphorylationSemantic proximity Read

Signalling In The Epidermis: The E2f Cell Cycle Regulatory Pathway In Epidermal Morphogenesis, Regeneration And TransformationSemantic proximity Read

Dual Modes of Gene Regulation by CDK12Semantic proximity Read

CDK9 as an Appealing Target for Therapeutic InterventionsSemantic proximity Read

Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transportSemantic proximity Read

Cyclin K goes with Cdk12 and Cdk13Semantic proximity Read

Human skin specific long noncoding RNA <i>HOXC13-AS</i> regulates epidermal differentiation by interfering with Golgi-ER retrograde transportSemantic proximity Read

Joint changes in RNA, RNA polymerase II, and promoter activity through the cell cycle identify non-coding RNAs involved in proliferationSemantic proximity Read

Role and therapeutic potential of CDK12 in human cancers.Semantic proximity Read

The long non-coding RNA LINC00941 modulates MTA2/NuRD occupancy to suppress premature human epidermal differentiationSemantic proximity Read