Back to search

Article

Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen <i>Cryptococcus deneoformans</i>

2022-06-10

Abstract excerpt

We recently reported transposon mutagenesis as a significant driver of spontaneous mutations in the human fungal pathogen Cryptococcus deneoformans during murine infection. Mutations caused by transposable element (TE) insertion into reporter genes were dramatically elevated at high temperature (37° versus 30°) in vitro, suggesting that heat stress stimulates TE mobility in the Cryptococcus genome. To explore the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f238e8b3-fc15-5943-802f-d052a601bd17
DOI
10.1101/2022.06.10.495668
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen <i>Cryptococcus deneoformans</i>DOI 10.1101/2022.06.10.495668
Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen Cryptococcus deneoformansSemantic proximity
Temperature and genetic background drive mobilization of diverse transposable elements in a global human fungal pathogenSemantic proximity
Transposon mobilization in the human fungal pathogen <i>Cryptococcus deneoformans</i> is mutagenic during infection and promotes drug resistance <i>in vitro</i>Semantic proximity
Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitroSemantic proximity
Distinct routes to thermotolerance in the fungal pathogen <i>Cryptococcus neoformans</i>Semantic proximity
Distinct evolutionary trajectories following loss of RNA interference in <i>Cryptococcus neoformans</i>Semantic proximity
Rampant transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of a human fungal pathogenSemantic proximity
Distinct routes to thermotolerance in the fungal pathogen Cryptococcus neoformans.Semantic proximity
Giant transposons promote strain heterogeneity in a major fungal pathogenSemantic proximity
The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans.Semantic proximity
Rampant transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of a human fungal pathogenSemantic proximity
Giant transposons promote strain heterogeneity in a major fungal pathogen.Semantic proximity
Select a neighboring publication to make it the new centre.