Article

Akt activator SC79 stimulates antibacterial nitric oxide production from human nasal epithelial cells and increases macrophage phagocytosis <i>in vitro</i>

2022-11-01

Abstract excerpt

<h4>Background</h4> The role of the Akt serine/threonine kinase family in airway innate immunity is relatively unstudied compared with other pathways. Akt can phosphorylate and activate the endothelial nitric oxide synthase (eNOS) isoform expressed in airway epithelial ciliated cells. NO production by nasal epithelial cells often has antibacterial and antiviral effects. Increasing nasal epithelial NO production m...

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Literature Corpus work: 961cbfae-133d-5be9-89e5-e2511e568a76
DOI: 10.1101/2022.10.31.514559

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