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Gene-Engineered S. oneidensis MR-1 for In Situ Hirudin Production and Modulation of Lactate Catabolism to Combat Atherosclerosis

2024-06-14

Abstract excerpt

<title>Abstract</title> Atherosclerotic plaques are situated in the arterial intima. The rapid blood flow and high shear stress impede the adhesion of drug carriers to endothelial cells and their accumulation in plaques. Therefore, ensuring effective drug delivery and optimal accumulation within plaques is essential. The discovery of bacteria within atherosclerotic plaques and the rapid progress in bacterial t...

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Literature Corpus work: 96000c50-9b2c-5550-8387-718dc628e9f8
DOI: 10.21203/rs.3.rs-4469565/v1

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