Article

Hypoxia-Activated Small Molecule-Induced Gene Expression

2018-07-24

Abstract excerpt

Hypoxia, conditions of reduced oxygen, occur in a wide variety of biological contexts, including solid tumours and bacterial biofilms, which are relevant to human health. Consequently, the development of chemical tools to study hypoxia is vital. Here we report a hypoxia-activated small molecule-mediated gene expression system using a bioreductive prodrug of the inducer isopropyl 1-thio-β-D-galactopyranoside (IPTG)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 72a77d20-5ef4-50b4-85cf-4cd3dc63c0cb
DOI: 10.26434/chemrxiv.6852035.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypoxia-Activated Small Molecule-Induced Gene ExpressionDOI 10.26434/chemrxiv.6852035.v1Read

Magneto-Photonic Gene Circuit for Minimally Invasive Control of Gene Expression in Mammalian CellsSemantic proximity Read

Engineered <em>Escherichia coli </em>Strains as Therapeutic Agents in Reactive Oxygen Species (ROS)-Mediated Glioblastoma Treatment: A Systematic Review of Mechanisms, Efficacy, and ChallengesSemantic proximity Read

Structure-guided engineering of a fast genetically encoded sensor for real-time H <sub>2</sub> O <sub>2</sub> monitoringSemantic proximity Read

Engineered Bacteria for Short-Chain-Fatty-Acid-Repressed Expression of Biotherapeutic MoleculesSemantic proximity Read

Engineering bacterial motility towards hydrogen-peroxide.Semantic proximity Read

Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis via SYK activationSemantic proximity Read

Ultra-fast genetically encoded sensor for precise real-time monitoring of physiological and pathophysiological peroxide dynamicsSemantic proximity Read

Rapid, randomized development of genetically encoded FRET sensors for small molecules.Semantic proximity Read

Clinical Advances of Hypoxia-Activated Prodrugs in Combination With Radiation Therapy.Semantic proximity Read

A Riboswitch-Based Inducible Gene Expression System for MycobacteriaSemantic proximity Read

Tumor Specific Hypoxia-Activated Expression of Cardiac Peptides Using an Engineered Subtype of Escherichia Coli Suppresses Tumor Growth, Angiogenesis and Metastasis in Mouse Model of Breast CancerSemantic proximity Read

Seeing red; the development of pON.mCherry, a broad-host range constitutive expression plasmid for Gram-negative bacteria.Semantic proximity Read