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Expression screening and functional verification of recombinant hirudin from novel chassis cell <i>Chlamydomonas reinhardtii</i>

2025-09-26

Abstract excerpt

Hirudin is a potent anticoagulant peptide whose clinical application is limited by scarce natural supplies and the suboptimal activity of recombinant versions from conventional microbial hosts lacking key post-translational modifications. Here, for the first time, we establish the “Generally Regarded as Safe” (GRAS) microalga, Chlamydomonas reinhardtii , as a novel biological chassis for producing fully functiona...

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Literature Corpus work
a1a40ef6-6a3e-587d-8c29-e4cb8e1bf81c
DOI
10.1101/2025.09.25.678210
Open publication

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Expression screening and functional verification of recombinant hirudin from novel chassis cell <i>Chlamydomonas reinhardtii</i>DOI 10.1101/2025.09.25.678210
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