Article

Targeted blocking of gene splicing can dysregulate intron-embedded microRNAs

2024-12-05

Abstract excerpt

ASOs (antisense oligonucleotides) are a promising therapeutic approach for suppression, induction of gene expression or the correction of aberrant splicing. Addressing whether ASOs targeting genes embedded with intronic noncoding RNAs (ncRNAs) affect the expression and function of intronic ncRNAs is of importance to the success of ASOs in clinical trials. While studying the development of the zebrafish posterior p...

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Literature Corpus work: 95fc5991-0b32-5e2f-9e2a-b097af6ff4cf
DOI: 10.1101/2024.12.04.626772

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