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Pharmacological Inhibition of the Spliceosome SF3b Complex by Pladienolide-B Elicits Craniofacial Developmental Defects in Mouse and Zebrafish.

Birth defects research - 1 Nov 2024

Hoshino Yukiko, Liu Shujie, Furutera Toshiko, Yamada Takahiko, Koyabu Daisuke, Nukada Yuko, Miyazawa Masaaki, Yoda Tetsuya, Ichimura Koichiro, Iseki Sachiko, Tasaki Junichi, Takechi Masaki

Abstract excerpt

BACKGROUND: Mutations in genes encoding spliceosome components result in craniofacial structural defects in humans, referred to as spliceosomopathies. The SF3b complex is a crucial unit of the spliceosome, but model organisms generated through genetic modification of the complex do not perfectly mimic the phenotype of spliceosomopathies. Since the phenotypes are suggested to be determined by the extent of...

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PMID: 39494782
DOI: 10.1002/bdr2.2404
PMCID: PMC11579809

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