Article
Canadian COVID-19 host genetics cohort replicates known severity associations.
PLoS genetics - 1 Mar 2024
Garg Elika, Arguello-Pascualli Paola, Vishnyakova Olga, Halevy Anat R, Yoo Samantha, Brooks Jennifer D, Bull Shelley B, Gagnon France, Greenwood Celia M T, Hung Rayjean J, Lawless Jerald F, Lerner-Ellis Jordan, Dennis Jessica K, Abraham Rohan J S, Garant Jean-Michel, Thiruvahindrapuram Bhooma, Jones Steven J M, Strug Lisa J, Paterson Andrew D, Sun Lei, Elliott Lloyd T
Abstract excerpt
The HostSeq initiative recruited 10,059 Canadians infected with SARS-CoV-2 between March 2020 and March 2023, obtained clinical information on their disease experience and whole genome sequenced (WGS) their DNA. We analyzed the WGS data for genetic contributors to severe COVID-19 (considering 3,499 hospitalized cases and 4,975 non-hospitalized after quality control). We investigated the evidence for replication...
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