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The role of hedgehog acyltransferase & heparan sulphate proteoglycans in human sonic hedgehog signalling

2011-01-01

Abstract excerpt

Hedgehog proteins (Hh) are morphogens and major mediators in many developmental processes. Hh signalling is significant for many aspects of embryonic development, whereas dysregulation of this pathway is associated with several types of cancers. Hh proteins require dual lipidation and Heparan Sulfate Proteoglycans (HSPGs) for their proper distribution and signalling activity. My first aim was to study the role of...

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Literature Corpus work
95e220cc-466f-5310-81c8-29d5be4b5d99
DOI
10.25560/6837
Open publication

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