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Article

Heparan sulphate N-sulphotransferase activity: reaction mechanism and substrate recognition.

Biochemical Society transactions - 1 Apr 2003

Kakuta Y, Li L, Pedersen L C, Pedersen L G, Negishi M

Abstract excerpt

Human heparan sulphate N-deacetylase/N-sulphotransferase 1 sulphates the NH(3) (+) group of the glucosamine moiety of the heparan chain in heparan sulphate/heparin biosynthesis. An open cleft that runs perpendicular to the sulphate donor 3'-phosphoadenosine 5'-phosphosulphate may constitute the acceptor substrate-binding site of the sulphotransferase domain (hNST1) [Kakuta, Sueyoshi, Negishi and Pedersen (1999)...

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Identifiers

PMID: 12653630
DOI: 10.1042/bst0310331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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