Back to search

Article

Prophylactic Lipoxin A <sub>4</sub> Attenuates <i>Clostridioides difficile</i> Infection by Augmenting Epithelial Barrier and Resolving Inflammation

2026-02-05

Abstract excerpt

Clostridioides difficile infection (CDI) is a leading healthcare-associated diarrhea with high recurrence rates, partially due to antibiotic-induced dysbiosis and dysregulated host inflammation. Specialized pro-resolving mediators (SPMs), such as Lipoxin A 4 (LXA 4 ), offer promise in controlling excessive inflammation and promoting tissue repair, yet their role in CDI remains unexplored. Here, we developed a co...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ef803d6f-4333-5524-9489-a8b4ad5ea623
DOI
10.64898/2026.02.03.703554
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prophylactic Lipoxin A <sub>4</sub> Attenuates <i>Clostridioides difficile</i> Infection by Augmenting Epithelial Barrier and Resolving InflammationDOI 10.64898/2026.02.03.703554
Pro-inflammatory Pathways Contribute to Pathogenesis of <i>Clostridioides difficile</i> Infection in a Murine Model - A Spatial Transcriptomics StudySemantic proximity
A New Hypothesis for <em>Clostridioides difficile</em> Infection Vulnerability: Epithelial Damage and Inflammatory Repair May Prime the Host for InfectionSemantic proximity
<i>Clostridioides difficile</i> exploits toxin-mediated inflammation to alter the host nutritional landscape and exclude competitors from the gut microbiotaSemantic proximity
Antibiotics promote susceptibility to <i>C. difficile</i> infection through a CCR5-dependent immune responseSemantic proximity
<i>Clostridioides difficile</i> Toxins Alter Host Metabolic Pathway and Bile Acid Homeostasis Gene Expression In Colonic EpitheliumSemantic proximity
Non-invasive treatment of Clostridioides difficile infection with a human-origin probiotic cocktail through gut microbiome-gut metabolome modulationsSemantic proximity
Pro-restitutive <i>Bacteroides thetaiotaomicron</i> reprograms the transcriptome of intestinal epithelial cells by modulating the expression of genes essential for proliferation and migrationSemantic proximity
Dual RNA-seq identifies proteins and pathways modulated during <i>Clostridioides difficile</i> colonisationSemantic proximity
High-fat diet rewires gut host-microbiota relationship to derive worse outcomes following <i>Clostridioides difficile</i> infectionSemantic proximity
Immunocompetent High-Throughput Gut-on-Chip Model for Intestinal Microbes–Host Interaction StudiesSemantic proximity
A Leaky Human Colon Model Reveals Uncoupled Apical/Basal Cytotoxicity in Early <i>Clostridioides difficile</i> Toxin ExposureSemantic proximity
Butyrate enhances Clostridioides difficile sporulation <i>in vitro</i>Semantic proximity
Select a neighboring publication to make it the new centre.