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Article

Neoantigen immunogenicity landscapes and evolution of tumor ecosystems during immunotherapy with nivolumab.

Nature medicine - 1 Nov 2024

Alban Tyler J, Riaz Nadeem, Parthasarathy Prerana, Makarov Vladimir, Kendall Sviatoslav, Yoo Seong-Keun, Shah Rachna, Weinhold Nils, Srivastava Raghvendra, Ma Xiaoxiao, Krishna Chirag, Mok Juk Yee, van Esch Wim J E, Garon Edward, Akerley Wallace, Creelan Benjamin, Aanur Nivedita, Chowell Diego, Geese William J, Rizvi Naiyer A, Chan Timothy A

Abstract excerpt

Neoantigen immunoediting drives immune checkpoint blockade efficacy, yet the molecular features of neoantigens and how neoantigen immunogenicity shapes treatment response remain poorly understood. To address these questions, 80 patients with non-small cell lung cancer were enrolled in the biomarker cohort of CheckMate 153 (CA209-153), which collected radiographic guided biopsy samples before treatment and during...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39349627
DOI: 10.1038/s41591-024-03240-y
PMCID: PMC12066197

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