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Article

Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer.

Nature communications - 15 Jun 2026

Adler Keren M, Xu Haiqing, Gladstein Amy C, Irizarry-Negron Valerie M, Robertson Maggie R, Doerig Katherine R, Petrov Dmitri A, Winslow Monte M, Feldser David M

Abstract excerpt

The impact of cancer driving mutations on immunosurveillance throughout tumor development remains poorly understood. To better understand the contribution of tumor genotype to immunosurveillance, we generated and validated lentiviral-based vectors that create increasingly immunogenic neoantigens. This vector system is compatible with autochthonous Cre-regulated cancer models, CRISPR/Cas9-mediated somatic genome...

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Topics

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Share to Antigens, Neoplasm
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Tumor Suppressor

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Share to Lung Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Source

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Identifiers

PMID: 42297823
DOI: 10.1038/s41467-026-74023-x
PMCID: PMC13408662

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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