Article

Targeted Cancer Therapy Has Been Defined at a Narrow Biological Level—A Hierarchical and Semi-Quantitative Reassessment of Genomic, Redox, and Metabolic Targeting

2026-02-26

Abstract excerpt

“Targeted cancer therapy” is commonly operationalized as mutation-matched pharmacologic therapy. These therapies represent genuine scientific advances. However, population-level analyses indicate that eligibility for genome-targeted drugs remains in the low-teens percentage range, with estimated durable benefit affecting only a small single-digit fraction of metastatic patients once intratumoral heterogeneity (ITH...

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Literature Corpus work: 540bee88-4d91-5e80-8b13-dbddbb1e3316
DOI: 10.20944/preprints202602.1555.v1

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